POST-VACCINATION IMMUNITY: FORMATION AND ASSESSMENT OF EFFECTIVENESS IN THE POPULATION OF THE KHARKIV REGION
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Abstract
A complex mosaic of immune responses was identified among the population of the Kharkiv region during the administration of combination vaccines designed to prevent multiple infectious diseases. The majority of vaccinated individuals respond adequately to several components of combined vaccines simultaneously; however, groups of individuals can invariably be identified who exhibit either weak or strong responses to one, two, or several vaccine antigens included in the formulation. Assessment of immune system status is most appropriately conducted both upon completion of the primary immunisation schedule and thereafter. This makes it possible to decide whether further booster vaccinations may be unnecessary or, conversely, to determine the need for enhancement of the immune response. The implementation of serological monitoring would enable a more accurate determination of the true levels of herd immunity across different social groups and regions, facilitate the management of vaccination schedules, assess the effectiveness of vaccines and vaccination programmes, and allow the estimation of the quantities of vaccines, diagnostic tools, medicinal products, and public health efforts required to ensure comprehensive population protection.
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effectiveness of specific prophylaxis against vaccine-preventable infectious diseases, serological monitoring.
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